Objective To understand the sleep status of postmenopausal ethnic minority females in Guangxi Zhuang Autonomous Region and its influencing factors. Methods This study was based on the baseline survey of the "Prospective Cohort Study of Chronic Diseases in Guangxi Ethnic Minority Natural Population" (study subject recruitment was conducted from May 2018 to December 2019), and 3,948 postmenopausal ethnic minority females in Guangxi Zhuang Autonomous Region were selected as the subjects. The Pittsburgh sleep quality index (PSQI) scale was used to investigate the sleep status of the study subjects, and the multivariate logistic regression model was used to analyze influencing factors for their troubled sleep. Results The total PSQI of postmenopausal ethnic minority females in Guangxi Zhuang Autonomous Region was (4.8±3.1), and the detection rate of troubled sleep was 18.2% (total PSQI>7); their major sleep problems were sleep disorders (82.9%), insufficient sleep time (55.5%), and daytime dysfunction (50.1%). Chronic diseases (OR=1.854, 95%CI: 1.573-2.185, P<0.001) and increased age (OR=1.015, 95%CI: 1.003-1.027, P=0.013) were risk factors, and an increased body mass index (BMI) (OR=0.956, 95%CI: 0.932~0.980, P<0.001) was a protective factor for troubled sleep in postmenopausal ethnic minority females in Guangxi Zhuang Autonomous Region. Conclusion The detection rate of troubled sleep is relatively high in postmenopausal ethnic minority females in Guangxi Zhuang Autonomous Region, and the incidence of chronic diseases, age, and BMI are the major factors affecting their sleep.