Objective To systematically review the intervention effects of the Omaha system-based continuous nursing for patients with chronic heart failure (CHF). Methods Databases including CNKI, VIP, Wanfang, China Biomedical Literature Database, PubMed, Web of Science, Cochrane Library, and Embase were searched for randomized controlled trials, in which patients with CHF had been intervened by the Omaha system-based continuous nursing, from the databases' inception to 30 March 2023. Using the RevMan 5.4 software, a meta-analysis was carried out to evaluate the effects of the Omaha system-based continuous nursing in the intervention of CHF patients in terms of self-care ability, quality of life, nursing satisfaction, and readmission rate. Results Seven studies involving 672 research subjects were included. The results of the meta-analysis showed that the Omaha system-based continuous nursing could improve CHF patients' self-care ability [MD=11.16, 95%CI (7.49, 14.83), P<0.001], quality of life [MD=25.91, 95%CI (22.38, 29.44), P<0.001], and nursing satisfaction [RR=1.17, 95%CI (1.06, 1.29), P=0.002], while reducing their readmission rate [RR=0.15, 95%CI (0.04, 0.66), P=0.01]. Conclusion The Omaha system-based continuous nursing helps to enhance CHF patients' self-care abilities, quality of life, and nursing satisfaction while reducing readmission rates.