Objective To explore the effect of slow blood flow during percutaneous coronary intervention (PCI) on the occurrence of postoperative contrast-induced nephropathy (CIN) in acute ST segment elevation myocardial infarction (ASTEMI). Methods The clinical data of 210 ASTEMI patients were retrospectively analyzed, and the patients were divided into a CIN group or a non-CIN group according to whether they developed CIN after PCI. The multivariate logistic regression model was used to analyze influencing factors for CIN in ASTEMI patients after PCI, and the Spearman rank correlation analysis was used to explore the correlation between the slow blood flow during PCI and postoperative CIN in ASTEMI patients. Results Among the 210 ASTEMI patients, 46 developed CIN after PCI, with an incidence of 21.9%. There was no statistically significant difference in gender, age, body mass index, smoking history, past medical history (hypertension, diabetes mellitus, hyperlipidemia, PCI, stroke/transient ischemic attack), systolic blood pressure, diastolic blood pressure, the proportion of patients with lesional blood vessel count ≥2, culprit blood vessel, Killip classification at admission, ventricular ejection fraction, white blood cell count, hemoglobin level, platelet count, blood urea nitrogen level, or preoperative TIMI grade between the CIN group and the non-CIN group (all P>0.05); the heart rate, contrast agent dose, serum creatinine (Scr) level, and incidence of slow blood flow in the CIN group were faster/larger/higher than those in the non-CIN group, and there was a statistically significant difference in the postoperative TIMI grade between the two groups (all P<0.05). The results of multivariate logistic regression analysis showed that a fast heart rate, a large dose of contrast agent, a high Scr level, and the occurrence of intraoperative slow blood flow were independent risk factors, while postoperative TIMI grade 3 was a protective factor for postoperative CIN in ASTEMI patients (all P<0.05). The occurrence of slow blood flow during PCI positively correlated with the occurrence of CIN after PCI in ASTEMI patients (rs=0.233, P<0.05). Conclusion Slow blood flow during PCI is an independent risk factor for CIN after PCI in ASTEMI patients. ASTEMI patients suffering from slow blood flow during PCI need to be intervened in a practical and effective way to reduce the occurrence of CIN after PCI and improve the prognosis for the patients.

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